Description

Diethyl-[6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its pyrimidine and pyrrolidine motifs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex, biologically active molecules.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for pharmacological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	Diethyl-[6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride
CAS No.	1353994-66-7
Molecular Formula	C12H21ClN4O
Molecular Weight	272.77 g/mol
Synonyms	Diethyl(6-{[(3R)-pyrrolidin-3-yl]oxy}pyrimidin-4-yl)amine hydrochloride; (R)-N,N-Diethyl-6-(pyrrolidin-3-yloxy)pyrimidin-4-amine hydrochloride; 4-Pyrimidinamine, N,N-diethyl-6-[(3R)-3-pyrrolidinyl]oxy]-, hydrochloride; 1353994-66-7; (R)-Diethyl-(6-(pyrrolidin-3-yloxy)pyrimidin-4-yl)amine HCl
EINECS	Contact for details

Quality Control

Our Diethyl-[6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.