Description

(S)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of targeted therapeutic agents, particularly in kinase inhibitor research. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for kinase-targeted therapies.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in oncology and immunology research programs.
• Preclinical Development: Serves as a critical material for producing batches of candidate drugs for pharmacological and toxicological evaluation.
• Process Chemistry: Employed in route scouting and scale-up studies to develop efficient and cost-effective manufacturing processes for novel therapeutics.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(S)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353994-21-4
Molecular Formula	C20H30N6O2
Molecular Weight	386.49 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-(cyclopropylamino)pyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-(cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine; BOC-Protected Pyrrolidine Pyrimidine Intermediate; UNII-8Q8F3T3S6U; 1-Pyrrolidinecarboxylic acid, 3-[(6-(cyclopropylamino)-4-pyrimidinyl)amino]-, 1,1-dimethylethyl ester, (3S)-; (S)-tert-Butyl 3-((6-(cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of (S)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols suitable for pharmaceutical R&D and cGMP starting material applications. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure consistent identity, purity, and performance. Certificates of Analysis (COA) detailing HPLC purity, chiral assay, residual solvents, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.