Description

3-(6-Amino-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially within oncology and antiviral research pipelines.
• Kinase Inhibitor Development: Used as a core scaffold or a functionalized fragment for constructing molecules that modulate kinase activity, a key target in cancer therapy.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes to improve drug potency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Bioconjugation & Probe Synthesis: The amino and ester functional groups make it suitable for creating chemical probes or conjugates for biochemical and diagnostic applications.

Basic Information

Product Name	3-(6-Amino-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353987-41-3
Molecular Formula	C15H24N4O3
Molecular Weight	308.38 g/mol
Synonyms	1-Boc-3-((6-aminopyrimidin-4-yloxy)methyl)piperidine; tert-Butyl 3-(((6-aminopyrimidin-4-yl)oxy)methyl)piperidine-1-carboxylate; 3-((6-Aminopyrimidin-4-yloxy)methyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-((6-aminopyrimidin-4-yloxy)methyl)piperidine; BOC-3-((6-Amino-4-pyrimidinyloxy)methyl)piperidine; 3-[(6-Aminopyrimidin-4-yl)oxymethyl]piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-(6-Amino-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring ICH stability guidelines or cGMP compliance upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container sealed to protect from moisture and incompatible materials such as strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.