Description

4-[(6-Methoxy-Pyrimidin-4-Yl)-Methyl-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• API Synthesis: Integral to the production route of final Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperidine-pyrimidine core structure.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP manufacturing of clinical trial materials and commercial drug substances.
• Biochemical Tool Compound: May be utilized in biochemical assays to study specific enzyme interactions and biological pathways.

Basic Information

Product Name	4-[(6-Methoxy-Pyrimidin-4-Yl)-Methyl-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353987-31-1
Molecular Formula	C16H26N4O3
Molecular Weight	322.41 g/mol
Synonyms	tert-Butyl 4-[(6-methoxypyrimidin-4-yl)(methyl)amino]piperidine-1-carboxylate; 1-Boc-4-[(6-methoxy-4-pyrimidinyl)methylamino]piperidine; 4-[(6-Methoxy-4-pyrimidinyl)methylamino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-[(6-methoxypyrimidin-4-yl)(methyl)amino]piperidine; 4-(N-Methyl-N-(6-methoxypyrimidin-4-yl)amino)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to verify identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing all critical quality attributes. Our quality management system supports development under research, non-GMP, and cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and potential degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.