Description

4-Ethoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant commercial and research interest. Its value lies in its critical role as a key building block in the synthesis of advanced pharmaceutical compounds, particularly for antiviral therapies. This product is essential for R&D laboratories, process development chemists, and manufacturers in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Primary use as a crucial synthetic precursor in the development and manufacturing of novel antiviral drugs, specifically non-nucleoside reverse transcriptase inhibitors (NNRTIs).
• Antiviral Drug Synthesis: Serves as a core scaffold for constructing active pharmaceutical ingredients (APIs) targeting HIV and other retroviral infections.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the discovery of new therapeutic candidates in virology and oncology research programs.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs) under GMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.
• Custom Synthesis Building Block: Provides a versatile piperazine-pyrimidine core for contract research organizations (CROs) and CDMOs developing proprietary compounds for clients.

Basic Information

Product Name	4-Ethoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride
CAS No.	1353985-71-3
Molecular Formula	C12H21N5OS • HCl
Molecular Weight	319.85 g/mol (Free base: 283.39 g/mol)
Synonyms	4-Ethoxy-6-(3-methyl-1-piperazinyl)-2-(methylthio)pyrimidine Hydrochloride; 2-(Methylthio)-4-ethoxy-6-(3-methyl-1-piperazinyl)pyrimidine HCl; NNRTI Intermediate 1353985-71-3; 6-(3-Methylpiperazin-1-yl)-4-ethoxy-2-methylsulfanylpyrimidine Hydrochloride; 4-Ethoxy-2-methylsulfanyl-6-(3-methylpiperazin-1-yl)pyrimidine Hydrochloride; CAS 1353985-71-3; 2-(Methylmercapto)-4-ethoxy-6-(3-methyl-1-piperazinyl)pyrimidine Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.