Description

4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

This specialized intermediate is designed for high-value synthesis applications, primarily within the pharmaceutical and advanced research sectors.

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those containing piperazine and pyrimidine pharmacophores.
• API Development: Used in research and development for constructing the core scaffold of potential new active pharmaceutical ingredients.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of target molecules under Good Manufacturing Practice (GMP) conditions where applicable.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs for global markets.

Basic Information

Product Name	4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353985-37-1
Molecular Formula	C17H26N4O3S
Molecular Weight	366.48 g/mol
Synonyms	4-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester; 2-Methyl-4-[6-methoxy-2-(methylsulfanyl)pyrimidin-4-yl]piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(6-methoxy-2-(methylthio)pyrimidin-4-yl)-2-methylpiperazine-1-carboxylate; 1-Boc-4-(6-methoxy-2-methylsulfanyl-pyrimidin-4-yl)-2-methyl-piperazine; CAS 1353985-37-1; BOC-protected piperazine-pyrimidine intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthesis workflows. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity (HPLC), identity (NMR, IR), and impurity profiles. We support development under quality agreements and can supply material suitable for use in GMP-regulated environments upon request and qualification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.