Description

(1R,4R)-4-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Cyclohexanol CAS NO 1353980-65-0 is a high-purity, chiral organic compound featuring a cyclohexanol core substituted with a cyclopropylamino-pyrimidine moiety. This compound is of significant interest as a key pharmaceutical intermediate or active pharmaceutical ingredient (API) building block in medicinal chemistry research and development. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the research of kinase inhibitors due to its pyrimidine structure.
• Chemical Biology Probes: Employed in the development of chemical probes to study specific biological targets and mechanisms.
• Custom Synthesis: A starting material for the custom synthesis of complex, high-value molecules for preclinical and clinical studies.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(1R,4R)-4-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Cyclohexanol
CAS No.	1353980-65-0
Molecular Formula	C13H21N5O
Molecular Weight	263.34 g/mol
Synonyms	(1R,4R)-4-[(6-Cyclopropylamino-4-pyrimidinyl)amino]cyclohexanol; 4-[(6-Cyclopropylamino-4-pyrimidinyl)amino]cyclohexanol, (1R,4R)-; trans-4-[(6-Cyclopropylamino-4-pyrimidinyl)amino]cyclohexanol; (1R,4R)-4-[(6-Cyclopropylamino-pyrimidin-4-yl)amino]-cyclohexanol; Cyclohexanol, 4-[(6-(cyclopropylamino)-4-pyrimidinyl)amino]-, (1R,4R)-; CAS 1353980-65-0
EINECS	Contact for details

Quality Control

Our (1R,4R)-4-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Cyclohexanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.