Description

4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate critical for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, offering significant value in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for clinical research.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries and exploring novel chemical entities in drug discovery programs.
• Protease Inhibitor Development: The piperidine and pyrimidine motifs make it valuable for research into protease inhibitors, a major class of therapeutic agents.
• Kinase Inhibitor Synthesis: Serves as a key intermediate in the development of kinase inhibitors, which are pivotal in targeted cancer therapies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353980-32-1
Molecular Formula	C16H26N4O3S
Molecular Weight	354.47 g/mol
Synonyms	4-[(6-Methoxy-2-methylsulfanylpyrimidin-4-yl)amino]piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)piperidine-1-carboxylate; 1-Boc-4-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)piperidine; 4-(6-Methoxy-2-(methylthio)pyrimidin-4-ylamino)piperidine-1-carboxylic acid tert-butyl ester; BOC-4-(6-Methoxy-2-methylmercaptopyrimidin-4-ylamino)piperidine
EINECS	Contact for details

Quality Control

Our 4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.