Description

4-Methoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant interest in modern organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic structures. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its precise chemical functionality, which enables the construction of targeted molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and scale-up of new APIs.
• Chemical Biology & Medicinal Chemistry: Used in the design and synthesis of chemical probes and libraries for high-throughput screening and target validation.
• Process Chemistry & Route Scouting: Employed in optimizing synthetic pathways for cost-effective and scalable manufacturing of complex molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical and biotechnology industries.
• Academic Research: Utilized in university and institutional labs for pioneering studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	4-Methoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride
CAS No.	1353980-29-6
Molecular Formula	C11H19N5OS • HCl
Molecular Weight	305.83 g/mol (Free base: 269.37 g/mol)
Synonyms	4-Methoxy-6-(3-methylpiperazin-1-yl)-2-(methylthio)pyrimidine hydrochloride; 2-(Methylthio)-4-methoxy-6-(3-methyl-1-piperazinyl)pyrimidine hydrochloride; 4-Methoxy-6-(3-methyl-1-piperazinyl)-2-(methylthio)pyrimidine HCl; 2-Methylsulfanyl-4-methoxy-6-(3-methyl-piperazin-1-yl)-pyrimidine hydrochloride; CAS 1353980-29-6
EINECS	Contact for details

Quality Control

Our 4-Methoxy-6-(3-Methyl-Piperazin-1-Yl)-2-Methylsulfanyl-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.