Description

4-Ethoxy-2-Methylsulfanyl-6-(Piperidin-3-Yloxy)-Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1353980-16-1. This compound is critical for research and development in medicinal chemistry, serving as a key building block for novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

This specialized pyrimidine derivative is designed for advanced synthetic applications. Its primary and potential uses include:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new molecular entities.
• Kinase Inhibitor Development: Serves as a core scaffold or substituent in the synthesis of compounds targeting kinase enzymes, relevant in oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological mechanisms and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and methodology development.

Basic Information

Product Name	4-Ethoxy-2-Methylsulfanyl-6-(Piperidin-3-Yloxy)-Pyrimidine Hydrochloride
CAS No.	1353980-16-1
Molecular Formula	C13H22ClN3O2S
Molecular Weight	319.85 g/mol
Synonyms	4-Ethoxy-2-(methylthio)-6-(3-piperidinyloxy)pyrimidine hydrochloride; 6-(3-Piperidinyloxy)-4-ethoxy-2-(methylthio)pyrimidine hydrochloride; 4-ethoxy-2-methylsulfanyl-6-piperidin-3-yloxy-pyrimidine;hydrochloride; 1353980-16-1; 4-Ethoxy-2-methylthio-6-(3-piperidyloxy)pyrimidine HCl; 4-Ethoxy-2-(methylsulfanyl)-6-(piperidin-3-yloxy)pyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2-Methylsulfanyl-6-(Piperidin-3-Yloxy)-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available for every lot. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.