Description

1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-[1,4]Diazepane Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes for new chemical entities.
• Active Pharmaceutical Ingredient (API) Development: A crucial precursor in the multi-step synthesis of complex heterocyclic compounds intended for clinical evaluation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel compounds for preclinical and clinical trials.
• Academic Research: Employed in university and institutional laboratories for studying diazepane and pyrimidine chemistry and their biological activities.

Basic Information

Product Name	1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-[1,4]Diazepane Hydrochloride
CAS No.	1353967-11-9
Molecular Formula	C11H18ClN4S • HCl
Molecular Weight	307.72 g/mol (Free base: 271.81 g/mol)
Synonyms	1-(6-Chloro-2-(methylthio)pyrimidin-4-yl)-1,4-diazepane hydrochloride; 4-(1,4-Diazepan-1-yl)-6-chloro-2-(methylsulfanyl)pyrimidine hydrochloride; 6-Chloro-2-(methylthio)-4-(1,4-diazepan-1-yl)pyrimidine hydrochloride; 1,4-Diazepane, 1-(6-chloro-2-(methylthio)-4-pyrimidinyl)-, hydrochloride; 1353967-11-9; UNII-8G4F6V8Q4H; 8G4F6V8Q4H
EINECS	Contact for details

Quality Control

Our 1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-[1,4]Diazepane Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment to verify identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.