Description

2-(4-Chloromethyl-Piperidin-1-Yl)-5-Fluoro-Pyrimidine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it combines a reactive chloromethyl handle with a fluorinated pyrimidine core, enabling precise molecular construction in complex pharmaceutical and agrochemical intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides that require fluorinated pyrimidine motifs for enhanced activity and stability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for constructing molecular probes and ligands used in target identification and validation studies.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where its specific heterocyclic structure imparts desired electronic or physical properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(4-Chloromethyl-Piperidin-1-Yl)-5-Fluoro-Pyrimidine
CAS No.	1353966-24-1
Molecular Formula	C10H13ClFN3
Molecular Weight	229.68 g/mol
Synonyms	5-Fluoro-2-[(4-chloromethyl)piperidin-1-yl]pyrimidine; 1-(5-Fluoropyrimidin-2-yl)-4-(chloromethyl)piperidine; 2-(4-Chloromethyl-1-piperidinyl)-5-fluoropyrimidine; 4-(Chloromethyl)-1-(5-fluoropyrimidin-2-yl)piperidine; 5-Fluoro-2-(4-chloromethylpiperidin-1-yl)pyrimidine; 2-(4-Chloromethylpiperidin-1-yl)-5-fluoropyrimidine; 1-(5-Fluoro-2-pyrimidinyl)-4-(chloromethyl)piperidine
EINECS	Contact for details

Quality Control

Our 2-(4-Chloromethyl-Piperidin-1-Yl)-5-Fluoro-Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research and cGMP manufacturing, depending on the required grade.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.