Description

5-Fluoro-2-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern drug discovery. Its core value lies in its pyrimidine and piperidine scaffold, which is a privileged structure for developing bioactive molecules targeting various therapeutic areas. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly those focused on synthesizing novel small-molecule candidates for oncology, neurology, and antiviral applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved potency and selectivity.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and target validation.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research-scale synthesis of potential active ingredients for preclinical and clinical studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in their discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug design methodologies.

Basic Information

Product Name	5-Fluoro-2-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride
CAS No.	1353965-96-4
Molecular Formula	C10H15FN3O•HCl
Molecular Weight	245.71 g/mol (Free base) / 282.17 g/mol (HCl salt)
Synonyms	5-Fluoro-2-((piperidin-4-yl)methoxy)pyrimidine hydrochloride; 2-((4-Piperidinyl)methoxy)-5-fluoropyrimidine hydrochloride; 5-Fluoro-2-(4-piperidinylmethoxy)pyrimidine HCl; 5-Fluoro-2-(piperidin-4-ylmethoxy)pyrimidine hydrochloride; 1353965-96-4; 5-Fluoro-2-(4-piperidylmethoxy)pyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen or argon atmosphere) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.