Description

4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a versatile piperazine-pyrimidine scaffold for constructing novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in kinase inhibitor research.
• Medicinal Chemistry R&D: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a crucial precursor in the multi-step manufacturing process of complex active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353958-74-3
Molecular Formula	C15H24N4O3S
Molecular Weight	340.44 g/mol
Synonyms	tert-Butyl 4-(6-methoxy-2-(methylthio)pyrimidin-4-yl)piperazine-1-carboxylate; 4-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(6-methoxy-2-methylsulfanyl-pyrimidin-4-yl)-piperazine; BOC-Piperazine-Pyrimidine Intermediate; 1353958-74-3
EINECS	Contact for details

Quality Control

Our 4-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.