Description

4-[(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for research and development of new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for producing target APIs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	4-[(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353958-26-5
Molecular Formula	C18H28N4O3S
Molecular Weight	380.50 g/mol
Synonyms	tert-Butyl 4-({[(6-methoxy-2-(methylthio)pyrimidin-4-yl]amino}methyl)piperidine-1-carboxylate; 1-Boc-4-({[6-methoxy-2-(methylthio)pyrimidin-4-yl]amino}methyl)piperidine; 4-({[6-Methoxy-2-(methylsulfanyl)pyrimidin-4-yl]amino}methyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 4-[(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester; 1,1-Dimethylethyl 4-({[6-methoxy-2-(methylthio)pyrimidin-4-yl]amino}methyl)-1-piperidinecarboxylate; 4-({[6-Methoxy-2-(methylthio)pyrimidin-4-yl]amino}methyl)piperidine-1-carboxylic acid tert-butyl ester; 1353958-26-5; Boc-protected aminomethylpyrimidine intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical R&D and manufacturing. Quality is verified through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.