Description

[6-(4-Aminomethyl-Piperidin-1-Yl)-Pyrimidin-4-Yl]-Cyclopropyl-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs) for targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its piperidine-pyrimidine scaffold.
• Kinase Inhibitor Development: Serves as a core structural component in the research and development of selective kinase inhibitors.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CRAMOs) for the custom synthesis of complex molecules for client projects.
• Bioconjugation & Probe Synthesis: The aminomethyl group provides a handle for bioconjugation, useful in creating chemical probes for biochemical assays.

Basic Information

Product Name	[6-(4-Aminomethyl-Piperidin-1-Yl)-Pyrimidin-4-Yl]-Cyclopropyl-Amine Hydrochloride
CAS No.	1353956-27-0
Molecular Formula	C13H22ClN5
Molecular Weight	283.80 g/mol
Synonyms	Cyclopropyl-[6-(4-aminomethylpiperidin-1-yl)pyrimidin-4-yl]amine hydrochloride; N-Cyclopropyl-6-(4-aminomethyl-1-piperidinyl)-4-pyrimidinamine hydrochloride; 4-Pyrimidinamine, N-cyclopropyl-6-[(4-aminomethyl-1-piperidinyl)]-, hydrochloride; 6-(4-Aminomethylpiperidin-1-yl)-N-cyclopropylpyrimidin-4-amine hydrochloride; CAS 1353956-27-0
EINECS	Contact for details

Quality Control

Our [6-(4-Aminomethyl-Piperidin-1-Yl)-Pyrimidin-4-Yl]-Cyclopropyl-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.