Description

4-Ethoxy-2-Methylsulfanyl-6-Piperazin-1-Yl-Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is essential for R&D laboratories, process development chemists, and manufacturers engaged in the production of specialized fine chemicals and potential drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug molecules, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probe Development: Serves as a starting material for creating molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Reference Standard: Used as an analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis & Contract Manufacturing: A key material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	4-Ethoxy-2-Methylsulfanyl-6-Piperazin-1-Yl-Pyrimidine Hydrochloride
CAS No.	1353956-01-0
Molecular Formula	C11H19N5OS • HCl
Molecular Weight	305.83 g/mol (Free base: 269.37 g/mol)
Synonyms	4-Ethoxy-2-(methylthio)-6-(piperazin-1-yl)pyrimidine hydrochloride; 2-(Methylsulfanyl)-4-ethoxy-6-piperazin-1-ylpyrimidine hydrochloride; 6-(1-Piperazinyl)-4-ethoxy-2-(methylthio)pyrimidine hydrochloride; 4-Ethoxy-2-methylmercapto-6-piperazin-1-yl-pyrimidine HCl; CAS 1353956-01-0
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2-Methylsulfanyl-6-Piperazin-1-Yl-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.