Description

6-(Piperidin-4-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1353955-14-2. This compound is a critical building block in modern medicinal chemistry, valued for its role in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel small-molecule drugs.
• Kinase Inhibitor Synthesis: Used in the construction of complex molecular scaffolds targeting specific kinase enzymes for cancer therapy.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Integral to the synthesis of Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions for clinical trials and commercial production.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical and pharmacological assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	6-(Piperidin-4-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride
CAS No.	1353955-14-2
Molecular Formula	C9H15ClN4O
Molecular Weight	230.69 g/mol
Synonyms	4-Amino-6-(4-piperidinyloxy)pyrimidine hydrochloride; 6-(4-Piperidyloxy)pyrimidin-4-amine hydrochloride; 4-Pyrimidinamine, 6-(4-piperidinyloxy)-, hydrochloride; 6-(Piperidin-4-yloxy)pyrimidin-4-amine HCl; 1353955-14-2; 6-(4-Piperidinyloxy)-4-pyrimidinamine monohydrochloride
EINECS	Contact for details

Quality Control

Our 6-(Piperidin-4-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with the standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.