Description

4-(6-Ethoxy-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a pyrimidine substituent. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The structural motif is valuable for creating inhibitors of specific enzymes, such as kinases or proteases.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target validation.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs performing bespoke synthetic routes for clients.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	4-(6-Ethoxy-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353955-09-5
Molecular Formula	C16H26N4O3
Molecular Weight	322.41 g/mol
Synonyms	tert-Butyl 4-[(6-ethoxypyrimidin-4-yl)amino]piperidine-1-carboxylate; 1-Boc-4-[(6-ethoxy-4-pyrimidinyl)amino]piperidine; 4-[(6-Ethoxypyrimidin-4-yl)amino]piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(6-ethoxypyrimidin-4-yl)amino]piperidine; Boc-4-(6-ethoxy-pyrimidin-4-ylamino)-piperidine; 4-(6-Ethoxy-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester; Piperidine-1-carboxylic acid, 4-[(6-ethoxy-4-pyrimidinyl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-(6-Ethoxy-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.