Description

3-(6-Methoxy-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and a methoxypyrimidine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with improved efficacy and safety profiles.
• Protease Inhibitor Development: The structural motifs present are valuable in the design and synthesis of protease inhibitors, a major class of therapeutic agents.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions for clinical trial material.
• Chemical Library Production: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis methodology and bioorganic chemistry.

Basic Information

Product Name	3-(6-Methoxy-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353954-98-9
Molecular Formula	C16H25N3O4
Molecular Weight	323.39 g/mol
Synonyms	1-Boc-3-((6-methoxypyrimidin-4-yloxy)methyl)piperidine; tert-Butyl 3-((6-methoxypyrimidin-4-yloxy)methyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-((6-methoxypyrimidin-4-yloxy)methyl)piperidine; 3-[(6-Methoxypyrimidin-4-yl)oxymethyl]piperidine-1-carboxylic acid tert-butyl ester; Boc-3-((6-MeO-Pyrimidin-4-yloxy)methyl)piperidine; Piperidine-1-carboxylic acid, 3-[(6-methoxy-4-pyrimidinyl)oxy]methyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(6-Methoxy-Pyrimidin-4-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for demanding R&D and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.