Description

n-(3-Fluoro-Benzyl)-Cyclohexane-1,2-Diamine Hydrochloride is a high-purity, fluorinated diamine hydrochloride salt with significant synthetic utility. This compound serves as a versatile chiral building block and intermediate in advanced organic synthesis, enabling the introduction of a fluorine-substituted benzyl moiety and a cyclohexane diamine scaffold. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of novel active pharmaceutical ingredients (APIs) and chiral catalysts.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Ligand Synthesis: Precursor for the development of chiral ligands used in asymmetric catalysis and metal complexation.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex fluorinated organic molecules for agrochemicals and specialty materials.
• Research & Development: Used in academic and industrial R&D laboratories for exploring new synthetic methodologies and structure-activity relationships (SAR).
• Peptidomimetic Chemistry: Incorporation into peptide backbones to create modified structures with enhanced metabolic stability or binding affinity.

Basic Information

Product Name	n-(3-Fluoro-Benzyl)-Cyclohexane-1,2-Diamine Hydrochloride
CAS No.	1353954-71-8
Molecular Formula	C13H20ClFN2
Molecular Weight	258.76 g/mol
Synonyms	N-[(3-Fluorophenyl)methyl]cyclohexane-1,2-diamine hydrochloride; 1,2-Cyclohexanediamine, N1-[(3-fluorophenyl)methyl]-, hydrochloride (1:1); (1R,2R)-N1-[(3-Fluorophenyl)methyl]cyclohexane-1,2-diamine hydrochloride (if chiral); (1S,2S)-N1-[(3-Fluorophenyl)methyl]cyclohexane-1,2-diamine hydrochloride (if chiral); 3-Fluoro-N-(cyclohexane-1,2-diaminylmethyl)aniline hydrochloride; 3-Fluorobenzyl-cyclohexyl-1,2-diamine HCl; F-Bn-CHDA HCl
EINECS	Contact for details

Quality Control

Our n-(3-Fluoro-Benzyl)-Cyclohexane-1,2-Diamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and specifications can be tailored to meet specific project requirements for chiral purity or custom grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.