Description

[1-(6-Cyclopropylamino-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key building block with a protected amine and a cyclopropylamino-pyrimidine moiety. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel therapeutic agents, particularly within kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of targeted small-molecule drugs.
• Kinase Inhibitor Development: Used in research and production of potential kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of specialized APIs for clinical trials.
• Biochemical Research: May be used as a reference standard or probe compound in biochemical assays.

Basic Information

Product Name	[1-(6-Cyclopropylamino-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester
CAS No.	1353944-62-3
Molecular Formula	C17H27N5O2
Molecular Weight	333.43 g/mol
Synonyms	tert-Butyl N-[1-[6-(cyclopropylamino)pyrimidin-4-yl]piperidin-4-yl]carbamate; 1-(6-Cyclopropylamino-Pyrimidin-4-Yl)-Piperidin-4-Ylamine, N-BOC-protected; BOC-Piperidine-Pyrimidine Intermediate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-[6-(cyclopropylamino)-4-pyrimidinyl]piperidine; UNII-9I6JZ5P8C2; 1353944-62-3; BOC-4-Amino-1-(6-cyclopropylaminopyrimidin-4-yl)piperidine
EINECS	Contact for details

Quality Control

Our production of [1-(6-Cyclopropylamino-Pyrimidin-4-Yl)-Piperidin-4-Yl]-Carbamic Acid tert-Butyl Ester adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.