Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid is a sophisticated, optically active amino acid derivative protected with the Fmoc group, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the precise, sequential construction of complex peptides and peptidomimetics under mild conditions, which is essential for pharmaceutical research and development. This high-purity intermediate is specifically designed for use by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors, where it facilitates the discovery and scalable synthesis of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of peptide chains in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including GLP-1 analogs and other metabolic disorder treatments.
• Peptidomimetic Design: Incorporates non-natural amino acid structures into drug candidates to enhance metabolic stability and bioavailability.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Bioconjugation: Useful for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid
CAS No.	1352435-52-9
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-(S)-3-Amino-4-(4-methoxyphenyl)butyric acid; Fmoc-Ahpha(4-OMe)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(4-methoxyphenyl)butanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(4-methoxyphenyl)butanoic acid; Fmoc-3-Ahpha(4-MeO)-OH; Fmoc-3-Amino-4-(4-methoxyphenyl)butyric acid; Fmoc-Ahpha(4-MeO)-OH; Fmoc-AMPB-OH
EINECS	Contact for details

Quality Control

Our production of (9H-Fluoren-9-Yl)Methoxy]Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to confirm identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, including cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store at 2-8°C in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.