Description

6-Methyl-5-(Piperazin-1-Ylmethyl)Pyrimidine-2,4(1H,3H)-Dione Dihydrochloride is a high-purity, pharmaceutically relevant intermediate with significant value in modern drug discovery and development. Its core value lies in its role as a versatile building block for synthesizing novel therapeutic agents, particularly those targeting the central nervous system. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Used in the synthesis of compounds targeting neurological disorders and CNS pathways.
• Medicinal Chemistry: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Utilized in academic and industrial labs for studying enzyme interactions and biochemical mechanisms.

Basic Information

Product Name	6-Methyl-5-(Piperazin-1-Ylmethyl)Pyrimidine-2,4(1H,3H)-Dione Dihydrochloride
CAS No.	1351620-52-4
Molecular Formula	C10H18Cl2N4O2
Molecular Weight	297.18 g/mol
Synonyms	6-Methyl-5-(piperazin-1-ylmethyl)pyrimidine-2,4(1H,3H)-dione dihydrochloride; 5-(Piperazin-1-ylmethyl)-6-methyluracil dihydrochloride; 6-Methyl-5-(piperazin-1-ylmethyl)uracil dihydrochloride; 1351620-52-4; 6-Methyl-5-(piperazin-1-ylmethyl)-1H-pyrimidine-2,4-dione dihydrochloride
EINECS	Contact for details

Quality Control

Our 6-Methyl-5-(Piperazin-1-Ylmethyl)Pyrimidine-2,4(1H,3H)-Dione Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity, and impurities. We support development and commercial projects with material suitable for research use and can provide material manufactured under cGMP guidelines for advanced clinical stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.