Description

4-Chloro-2-Fluoro-5-Iodo-Phenylamine is a halogenated aniline derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated and iodinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the halogen atoms for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic core.
• Chemical Biology & Proteomics: Employed as a reagent for labeling and modifying biomolecules in research applications.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.
• Dye & Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and pigments.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Iodo-Phenylamine
CAS No.	1350475-34-1
Molecular Formula	C6H4ClFIN
Molecular Weight	271.46 g/mol
Synonyms	5-Amino-2-chloro-4-fluoro-1-iodobenzene; 2-Chloro-4-fluoro-5-iodoaniline; 4-Chloro-2-fluoro-5-iodobenzenamine; 1-Amino-4-chloro-2-fluoro-5-iodobenzene; Benzenamine, 4-chloro-2-fluoro-5-iodo-; 4-Chloro-2-fluoro-5-iodo-phenylamine; 2-Fluoro-4-chloro-5-iodoaniline; 5-Iodo-2-chloro-4-fluoroaniline
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Iodo-Phenylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.