Description

Fmoc-n-Me-D-Cys(Trt)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide sequence and stereochemistry, particularly for the incorporation of modified cysteine residues. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of therapeutic peptides, peptidomimetics, and research biochemicals. Its stability under SPPS conditions makes it a valuable building block for complex peptide assembly.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical R&D: For the discovery and development of novel therapeutic peptides targeting various diseases.
• Peptidomimetic Design: Incorporation of N-methylated and side-chain protected cysteine analogs to enhance metabolic stability and bioavailability of drug candidates.
• Bioconjugation: Serves as a precursor for introducing thiol-reactive sites or protected thiol handles into biomolecules.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used in mechanistic studies and target identification.
• Academic Research: A fundamental reagent in university and institutional labs for studying protein structure-function relationships.

Basic Information

Product Name	Fmoc-n-Me-D-Cys(Trt)-Oh
CAS No.	1349807-46-0
Molecular Formula	C38H33NO4S
Molecular Weight	599.74 g/mol
Synonyms	Fmoc-N-methyl-D-cysteine(Trt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-cysteine(S-trityl); Fmoc-N-Me-D-Cys(Trt)-OH; Fmoc-D-N-Me-Cys(Trt)-OH; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-3-(tritylsulfanyl)propanoic acid; N-Fmoc-N-methyl-D-cysteine(S-trityl); Fmoc-D-Cys(Me,Trt)-OH (common shorthand)
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-D-Cys(Trt)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and our quality commitment ensures the material meets the stringent requirements for peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.