Description

3-Fluoro-4-(Oxetan-3-Yloxy)Benzenamine is a high-value, multifunctional aromatic amine building block featuring both a fluorine substituent and an oxetane ether linkage. This unique molecular architecture makes it a critical intermediate for medicinal chemistry and advanced materials research, offering opportunities for structural diversification and property modulation. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the fluorine and oxetane groups can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for electronic chemicals used in display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, adhesion, or thermal properties.
• Cross-coupling Reactions: The aniline moiety makes it a suitable substrate for Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions.
• Academic & Contract Research: Employed in university and CRO laboratories for exploratory synthetic chemistry and method development projects.

Basic Information

Product Name	3-Fluoro-4-(Oxetan-3-Yloxy)Benzenamine
CAS No.	1349716-61-5
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	3-Fluoro-4-(oxetan-3-yloxy)aniline; 4-Amino-2-fluoro-1-(oxetan-3-yloxy)benzene; Benzenamine, 3-fluoro-4-(oxetan-3-yloxy)-; 1349716-61-5; 3-Fluoro-4-(3-oxetanyloxy)aniline; 3-Oxetanyl 3-fluoro-4-aminophenyl ether
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Oxetan-3-Yloxy)Benzenamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.