Description

(2-([-4-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ylethyl)Amine Hydrochloride CAS NO 1349716-58-0 is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine-thiophene hybrid structure. This compound is a critical building block in modern medicinal chemistry, valued for its role in modulating biological activity and enhancing drug-like properties. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Used in the construction of small molecule inhibitors targeting various kinases for cancer therapy.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation & Probe Development: The amine hydrochloride moiety allows for functionalization, useful in creating diagnostic probes or targeted drug conjugates.
• Agrochemical Research: Potential application in the synthesis of novel compounds for crop protection science.
• Academic & Contract Research: Supplied to universities and CROs for fundamental chemical and pharmacological research.

Basic Information

Product Name	(2-([-4-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ylethyl)Amine Hydrochloride
CAS No.	1349716-58-0
Molecular Formula	C11H11ClF3N3S
Molecular Weight	309.73 g/mol
Synonyms	2-((4-Thienyl)-6-(trifluoromethyl)pyrimidin-2-ylethyl)amine hydrochloride; 2-(2-Aminoethyl)-4-(thiophen-4-yl)-6-(trifluoromethyl)pyrimidine hydrochloride; 4-(Thiophen-4-yl)-6-(trifluoromethyl)-2-pyrimidineethanamine hydrochloride; 2-(4-Thienyl)-6-(trifluoromethyl)pyrimidine-2-ethylamine HCl; CAS 1349716-58-0
EINECS	Contact for details

Quality Control

Our (2-([-4-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ylethyl)Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.