Description

5-Fluoro-2-(Oxetan-3-Yloxy)Benzenamine is a high-value pharmaceutical intermediate featuring a unique oxetane ether linkage on an aniline core. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with improved metabolic stability and pharmacokinetic properties. It is primarily needed by R&D and process chemistry teams in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for small molecule drugs.
• Kinase Inhibitor Synthesis: Used in the construction of potent and selective kinase inhibitors, a major class of oncology and anti-inflammatory therapeutics.
• Protease Inhibitor Development: Serves as a building block for protease inhibitors targeting viral and other disease pathways.
• Chemical Biology & Probe Development: Employed in the synthesis of chemical probes for target identification and validation in drug discovery.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Academic & Contract Research: Used in university and CRO settings for exploratory medicinal chemistry and methodology development.

Basic Information

Product Name	5-Fluoro-2-(Oxetan-3-Yloxy)Benzenamine
CAS No.	1349715-85-0
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	3-[(2-Amino-4-fluorophenoxy)methyl]oxetane; 2-Amino-4-fluoro-1-(oxetan-3-yloxy)benzene; 5-Fluoro-2-(oxetan-3-yloxy)aniline; 5-Fluoro-2-(3-oxetanyloxy)benzenamine; Benzenamine, 5-fluoro-2-(oxetan-3-yloxy)-; 1349715-85-0; 5-Fluoro-2-(oxetane-3-yloxy)aniline
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Oxetan-3-Yloxy)Benzenamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profile is provided with every shipment. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.