Description

n-(3-Fluoro-4-Methoxybenzyl)Piperidin-4-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzylpiperidine amine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex APIs requiring a fluorinated benzylpiperidine moiety.
• Biochemical Tool Compound: Potential use in pharmacological assays and as a reference standard for analytical method development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(3-Fluoro-4-Methoxybenzyl)Piperidin-4-Amine Dihydrochloride
CAS No.	1349708-98-0
Molecular Formula	C13H19FN2O • 2HCl
Molecular Weight	307.22 g/mol (Free base: 238.31 g/mol)
Synonyms	4-Amino-1-[(3-fluoro-4-methoxyphenyl)methyl]piperidine dihydrochloride; 1-[(3-Fluoro-4-methoxyphenyl)methyl]piperidin-4-amine dihydrochloride; 3-Fluoro-4-methoxybenzylpiperidin-4-amine dihydrochloride; N-[(3-Fluoro-4-methoxyphenyl)methyl]-4-piperidinamine dihydrochloride; 1349708-98-0; 4-Piperidinamine, N-[(3-fluoro-4-methoxyphenyl)methyl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our n-(3-Fluoro-4-Methoxybenzyl)Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by FT-IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.