Description

2-Methyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate critical for modern drug discovery and development. This compound matters because it serves as a versatile and protected building block for synthesizing complex heterocyclic molecules, enabling the creation of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D teams and fine chemical manufacturers need this specific intermediate to accelerate the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing fused pyrido-pyrimidine scaffolds, a privileged structure in drug design.
• Research & Development (R&D): Essential for academic and industrial research laboratories exploring new chemical entities (NCEs) and structure-activity relationships (SAR).
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for the production of APIs under current Good Manufacturing Practice (cGMP) standards.
• Preclinical Studies: Used to prepare compounds for pharmacological screening, toxicology assessments, and early-stage development.

Basic Information

Product Name	2-Methyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1346808-81-8
Molecular Formula	C14H19N3O2
Molecular Weight	261.32 g/mol
Synonyms	tert-Butyl 2-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 6H-Pyrido[3,4-d]pyrimidine-7-carboxylic acid, 5,8-dihydro-2-methyl-, 1,1-dimethylethyl ester; 2-Methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester; 2-Methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-t-butyl carboxylate; Pyrido[3,4-d]pyrimidine tert-butyl ester derivative
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.