Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Rel- is a complex, high-purity pharmaceutical intermediate with a defined stereochemistry. This compound is of significant commercial importance for the research and development of novel active pharmaceutical ingredients (APIs), particularly in the antibacterial and quinolone antibiotic classes. It is primarily targeted at pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the synthesis of advanced therapeutic agents.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a critical building block in the multi-step synthesis of advanced-generation fluoroquinolone and related antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of target APIs under current Good Manufacturing Practice (cGMP) guidelines.
• Reference Standard: Can be utilized as a high-purity chemical reference standard for analytical method development, validation, and quality control testing.
• Custom Synthesis Projects: Acts as a starting material or advanced intermediate for custom synthesis and contract manufacturing organizations (CMOs) serving the pharma sector.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Rel-
CAS No.	1346747-14-5
Molecular Formula	C21H24FN3O4
Molecular Weight	401.43 g/mol
Synonyms	Rel-(4aR,7aR)-1-Cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (R,R)-Nemonoxacin Intermediate; Nemonoxacin Related Compound; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid; TG-873870 (Intermediate); ABT-492 Intermediate; (4aR,7aR)-enantiomer of the Quinolone Intermediate.
EINECS	Contact for details

Quality Control

This product is manufactured and controlled to meet the exacting standards required for pharmaceutical development. Our quality assurance system ensures rigorous testing for identity, purity, and potency, with typical purity levels exceeding 97% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chromatographic purity, chiral purity, residual solvents, and other critical parameters. We adhere to relevant quality management frameworks to ensure supply chain reliability and product consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (desired enantiomer)
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.