Description

5-(Trifluoromethylthio)Indoline-2,3-Dione is a high-value, specialized organic intermediate featuring a reactive indoline-2,3-dione (isatin) core functionalized with a trifluoromethylthio group. This compound matters for its unique combination of structural motifs, enabling the synthesis of novel molecules with potential biological activity and tailored physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for use in medicinal chemistry, as a building block for drug discovery, and in the development of advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethylthio group can enhance lipophilicity and metabolic stability.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries via derivatization at the isatin nitrogen or carbonyl groups for high-throughput screening.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or dyes due to its conjugated system and electron-withdrawing substituents.
• Chemical Biology Probe: Can be utilized to develop activity-based probes or inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	5-(Trifluoromethylthio)Indoline-2,3-Dione
CAS No.	1344718-26-8
Molecular Formula	C9H4F3NO2S
Molecular Weight	247.19 g/mol
Synonyms	5-(Trifluoromethylthio)isatin; 5-(Trifluoromethylsulfanyl)-1H-indole-2,3-dione; 5-(Trifluoromethylthio)-2,3-dihydro-1H-indole-2,3-dione; 5-(Trifluoromethylthio)indoline-2,3-dione; 5-(Trifluoromethylmercapto)isatin; 5-(Trifluoromethylsulfanyl)isatin; 2,3-Dioxo-5-(trifluoromethylthio)indoline; 1344718-26-8
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethylthio)Indoline-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from advanced techniques like HPLC, NMR, and MS. Our quality commitment aligns with the standards required for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.