Description

Val-Ala-Pab CAS NO 1343476-44-7 is a specialized peptide building block, specifically a valine-alanine p-aminobenzyl alcohol (Pab) derivative, widely used in the synthesis of advanced pharmaceutical intermediates. Its primary value lies in its role as a key component for constructing protease-activated prodrugs and targeted drug delivery systems, enabling enhanced therapeutic efficacy and reduced side effects. This high-purity intermediate is essential for research and development laboratories, as well as production facilities, in the pharmaceutical and biotechnology sectors focused on oncology and novel therapeutic modalities.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Prodrug Synthesis: Used in the construction of self-immolative linkers for protease-activated prodrugs, facilitating controlled drug release at disease sites.
• Peptide Chemistry: Serves as a protected dipeptide fragment in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: A valuable tool for drug discovery programs exploring novel linker technologies and targeted delivery platforms.
• Bioconjugation: Employed in the development of bioconjugates that link cytotoxic agents to antibodies, proteins, or other targeting molecules.

Basic Information

Product Name	Val-Ala-Pab
CAS No.	1343476-44-7
Molecular Formula	C17H25N3O4
Molecular Weight	335.40 g/mol
Synonyms	L-Valyl-L-alanine 4-aminobenzyl alcohol; Val-Ala-PAB; V-A-PABOH; Fmoc-Val-Ala-PAB; PAB Val-Ala; ADC Linker Val-Ala-PAB; Valine-Alanine-P-Aminobenzyl Alcohol; Protease Cleavable Linker Val-Ala-Pab
EINECS	Contact for details

Quality Control

Our Val-Ala-Pab is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of advanced intermediates, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.