Description

n-Fmoc-n-Cyclopropylglycine CAS NO 1342767-08-1 is a high-purity, non-proteinogenic amino acid derivative, specifically engineered for advanced peptide synthesis. This compound is a critical building block for introducing the constrained cyclopropylglycine moiety into peptide chains, which is essential for modulating biological activity and improving metabolic stability. It is primarily utilized by pharmaceutical researchers, peptide chemists, and biotechnology companies engaged in the development of novel therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, particularly those targeting proteases, GPCRs, and other biological targets where conformational restriction is beneficial.
• Peptidomimetic Design: Incorporates the rigid cyclopropyl group to create stable peptide analogs with enhanced bioavailability and receptor selectivity.
• Bioconjugation and Probe Development: Serves as a modified amino acid precursor for creating labeled peptides used in imaging, diagnostics, and affinity studies.
• Chemical Biology Studies: Employed to investigate protein-protein interactions and enzyme mechanisms by introducing specific structural perturbations into peptide sequences.
• Custom Peptide Service Production: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing for clients worldwide.

Basic Information

Product Name	n-Fmoc-n-Cyclopropylglycine
CAS No.	1342767-08-1
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Cpg-OH; (9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-cyclopropyl-2-hydroxy-1-(hydroxymethyl)ethyl]carbamate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-aminocyclopropane-1-carboxylic acid; Fmoc-1-Amino-1-cyclopropanecarboxylic acid; Fmoc-Acpc-OH; Nα-Fmoc-1-aminocyclopropane-1-carboxylic acid; (1R,2S)-1-[(Fmoc-amino)methyl]-2-cyclopropyl-1,2-ethanediol (related intermediate); Fmoc-Cyclopropylglycine
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-Cyclopropylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the exacting standards required for sensitive peptide synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.