Description

4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid is a high-value, fluorinated pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is a key strategy to modulate biological activity and metabolic stability. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical companies, and fine chemical producers focused on creating next-generation small molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated organic materials and liquid crystals with unique electronic properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Item	Detail
Product Name	4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid
CAS No.	1340535-05-8
Molecular Formula	C7H4F2N2O2
Molecular Weight	186.12 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-(difluoromethyl)-; 4-(Difluoromethyl)pyrimidine-5-carboxylic acid; Difluoromethyl-pyrimidine-carboxylic acid; DFMP-CA; CAS 1340535-05-8
EINECS	Contact for details

Quality Control

Our 4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.