Description

7-Chloro-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is a high-purity, heterocyclic organic compound serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which combines halogenated and fluorinated substituents on a fused triazolopyrimidine ring system, enabling precise structural modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning molecular properties.

Application

This specialized intermediate is designed for high-value synthesis and research applications, including:

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl and chloro groups contribute to bioactivity and metabolic stability.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	7-Chloro-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
CAS No.	1340394-63-9
Molecular Formula	C7H4ClF2N4
Molecular Weight	217.58 g/mol
Synonyms	7-Chloro-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine; 5-(Difluoromethyl)-7-chloro-[1,2,4]triazolo[1,5-a]pyrimidine; 7-Chloro-5-difluoromethyl-[1,2,4]triazolo[1,5-a]pyrimidine; [1,2,4]Triazolo[1,5-a]pyrimidine, 7-chloro-5-(difluoromethyl)-; CAS 1340394-63-9; 7-Chloro-5-difluoromethyl-1,2,4-triazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Our production of 7-Chloro-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for traceability and reliability, making it suitable for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.