Description

1-(2,2,2-Trifluoroethyl)Pyrimidine-2,4(1H,3H)-Dione is a high-value fluorinated pyrimidine derivative, a key building block in advanced organic synthesis. This compound is engineered to introduce the trifluoroethyl pharmacophore, which is critical for enhancing the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel nucleoside analogs and other active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer drug candidates.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the trifluoroethyl group can improve compound activity and environmental persistence.
• Chemical Biology Probe Development: Acts as a scaffold for creating labeled compounds or inhibitors to study enzymatic pathways and biological mechanisms.
• Material Science: Potential monomer or additive for creating specialty polymers with unique fluorine-based properties, such as altered surface energy or chemical resistance.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting custom synthesis and scale-up projects for client molecules.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	1340213-90-2
Molecular Formula	C6H5F3N2O2
Molecular Weight	194.11 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)uracil; 1-(Trifluoroethyl)uracil; 5-Trifluoroethyluracil (common misnomer, refers to substitution); 2,4(1H,3H)-Pyrimidinedione, 1-(2,2,2-trifluoroethyl)-; N1-(2,2,2-Trifluoroethyl)uracil; TFU (abbreviation); Uracil, 1-(trifluoroethyl)-; 1340213-90-2 (CAS synonym)
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2,2-Trifluoroethyl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.