Description

1-(2,4-Difluorophenyl)Cyclopentanamine CAS NO 1340120-25-3 is a high-purity, advanced pharmaceutical intermediate featuring a cyclopentylamine core substituted with a difluorophenyl group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine substitution for enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, antiviral drugs, and other specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural motif in the multi-step synthesis of complex APIs, leveraging the fluorine atoms for optimal drug-receptor interaction.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize pharmacological properties.
• Preclinical & Clinical Trial Material: Supplied as a critical raw material for producing batches of investigational new drugs for non-clinical and clinical studies.
• Contract Development and Manufacturing (CDMO): Sourced by CDMOs for custom synthesis projects and scale-up manufacturing under cGMP guidelines.
• Agrochemical Intermediate: Potential application in the synthesis of advanced crop protection agents and pesticides.

Basic Information

Product Name	1-(2,4-Difluorophenyl)Cyclopentanamine
CAS No.	1340120-25-3
Molecular Formula	C11H13F2N
Molecular Weight	197.22 g/mol
Synonyms	1-(2,4-Difluorophenyl)cyclopentanamine; 2,4-Difluoro-1-(cyclopentylamino)benzene; Cyclopentanamine, 1-(2,4-difluorophenyl)-; 1-(2,4-Difluorophenyl)cyclopentylamine; 1340120-25-3; 2,4-Difluoro-N-cyclopentylaniline; N-Cyclopentyl-2,4-difluoroaniline
EINECS	Contact for details

Quality Control

Our 1-(2,4-Difluorophenyl)Cyclopentanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.