Description

Lysine(Crotonyl)-Oh is a modified amino acid derivative featuring a crotonyl group, a key structural motif for advanced biochemical research and synthesis. This compound is essential for scientists developing novel peptide-based therapeutics and studying post-translational modifications like lysine crotonylation, a critical epigenetic marker. It serves as a vital building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, specialized intermediates for drug discovery and proteomics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel peptide drugs and targeted therapeutics.
• Biochemical Research: Critical for studying histone lysine crotonylation (Kcr) and its role in gene regulation and epigenetic pathways.
• Proteomics & Biomarker Discovery: Used as a standard or reagent in mass spectrometry-based proteomic analysis to identify and quantify crotonylated proteins.
• Peptide Synthesis: Serves as a specialized, protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Enzyme Substrate & Inhibitor Development: Utilized in the design and development of substrates or inhibitors for enzymes like histone deacetylases (HDACs) and acyltransferases.
• Chemical Biology Tool Development: Incorporated into activity-based probes and affinity tags for investigating protein-protein interactions and enzyme activity.

Basic Information

Product Name	Lysine(Crotonyl)-Oh
CAS No.	1338823-35-0
Molecular Formula	C9H16N2O3
Molecular Weight	200.24 g/mol
Synonyms	Nε-Crotonyl-L-lysine; L-Lysine, N6-(1-oxo-2-buten-1-yl)-; N6-Crotonyl-L-lysine; (2S)-2-Amino-6-[(2E)-but-2-enoylamino]hexanoic acid; Crotonylated Lysine; Lys(Crotonyl)-OH; Kcr derivative; Epigenetic research amino acid
EINECS	Contact for details

Quality Control

Our Lysine(Crotonyl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.