Description

tert-Butyl [1-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperidin-4-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a versatile building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in kinase inhibitor research.
• Medicinal Chemistry R&D: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a critical precursor in the multi-step manufacturing process of final active pharmaceutical ingredients.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Chemical Reference Standard: Can be used as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	tert-Butyl [1-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperidin-4-Yl]Carbamate
CAS No.	1338494-93-1
Molecular Formula	C14H18ClFN4O2
Molecular Weight	328.77 g/mol
Synonyms	Boc-4-Amino-1-(2-chloro-5-fluoropyrimidin-4-yl)piperidine; 1-Boc-4-Amino-1-(2-chloro-5-fluoropyrimidin-4-yl)piperidine; tert-Butyl N-[1-(2-chloro-5-fluoropyrimidin-4-yl)piperidin-4-yl]carbamate; 4-[[(tert-Butoxy)carbonyl]amino]-1-(2-chloro-5-fluoropyrimidin-4-yl)piperidine; 1-(2-Chloro-5-fluoropyrimidin-4-yl)-4-[(tert-butoxycarbonyl)amino]piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl [1-(2-Chloro-5-Fluoropyrimidin-4-Yl)Piperidin-4-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.