Description

Colistin B Sulfate Salt (~90%) is a high-purity, semi-synthetic derivative of the polymyxin class of antibiotics, specifically isolated from the colistin complex. This compound is critical for research and development in combating multidrug-resistant Gram-negative bacterial infections. It serves as a vital reference standard and active pharmaceutical ingredient (API) intermediate for pharmaceutical manufacturers, academic research institutions, and diagnostic kit developers focused on antimicrobial resistance (AMR) studies.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of colistin-based drugs in quality control laboratories.
• Antimicrobial Research: A key material for in-vitro studies on pharmacokinetics, pharmacodynamics, and the mechanism of action against resistant pathogens like Pseudomonas aeruginosa and Acinetobacter baumannii.
• API Intermediate: Serves as a starting material or precursor in the synthesis of finished dosage forms for colistin medications, including injections and inhalable solutions.
• Diagnostic Development: Employed in the formulation of culture media, susceptibility test strips, and other diagnostic tools for clinical microbiology.
• Veterinary Medicine Research: Applied in studies for developing treatments for bacterial infections in livestock and companion animals.

Basic Information

Product Name	Colistin B Sulfate Salt (~90%)
CAS No.	1338055-88-1
Molecular Formula	C52H98N16O13 • xH2SO4
Molecular Weight	~1170.5 (base)
Synonyms	Polymyxin E1 Sulfate; Colistin A Sulfate; Colistin Sulfate Component B; [1-[4,9-Diamino-1-oxo-1-[[2,3,4,5,6-pentahydroxy-6-(hydroxymethyl)cyclohexyl]amino]heptyl]-L-2,4-diaminobutanoyl-D-leucyl-L-α,γ-diaminobutanoyl-L-threonyl-L-α,γ-diaminobutanoic acid] Sulfate; Antibiotic Colistin B Sulfate; Colistin B Sulphate
EINECS	Contact for details

Quality Control

Every batch of our Colistin B Sulfate Salt is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, aligning with research and pharmaceutical industry expectations. A detailed Certificate of Analysis (COA) including results for assay, related substances, residual solvents, and microbiological tests is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccant and temperature-controlled environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	NLT 90.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities: NMT 5.0% Any individual impurity: NMT 2.0%
Water Content (KF)	NMT 8.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.05 EU/µg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.