Description

(2S)-2-(Fmoc-Amino)Dodecanoic Acid is a high-purity, non-natural amino acid derivative featuring a long-chain dodecanoic acid backbone protected by a base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is critically important as a specialized building block for the solid-phase peptide synthesis (SPPS) of lipopeptides and hydrophobic peptide sequences, where its extended aliphatic chain can modulate the physicochemical properties of the final product. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides, antimicrobial agents, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid building block for the controlled incorporation of lipophilic moieties into peptide chains.
• Lipopeptide Development: Essential for synthesizing peptide amphiphiles, antimicrobial lipopeptides, and vaccine adjuvants that require fatty acid conjugation.
• Hydrophobic Peptide Segment Synthesis: Used to introduce hydrophobic character into specific regions of a peptide to influence folding, membrane interaction, or solubility profiles.
• Bioconjugation and Probe Synthesis: Acts as a precursor for creating fluorescent or affinity-labeled peptide probes with enhanced membrane permeability.
• Pharmaceutical Research: Employed in the discovery and development of peptide-based drugs targeting metabolic disorders, infectious diseases, and oncology.
• Biomaterials and Self-Assembling Peptides: A component in designing peptide-based nanostructures, hydrogels, and delivery systems where alkyl chain length dictates assembly behavior.

Basic Information

Product Name	(2S)-2-(Fmoc-Amino)Dodecanoic Acid
CAS No.	1338002-17-7
Molecular Formula	C₂₆H₃₃NO₄
Molecular Weight	423.55 g/mol
Synonyms	Fmoc-Dodecanoic Acid; Fmoc-L-Dodecanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-dodecanoic Acid; N-Fmoc-L-aminododecanoic Acid; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]dodecanoic Acid; Fmoc-Dda-OH; Fmoc-L-Aminolauric Acid
EINECS	Contact for details

Quality Control

Our (2S)-2-(Fmoc-Amino)Dodecanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to ensure the material meets the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.