Description

1-Pyrrolidinecarboxylic Acid, 2-[(Carboxymethoxy)Methyl]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2R)- CAS NO 1335206-44-4 is a sophisticated chiral building block and protected amino acid derivative, specifically designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity, stereochemically defined intermediates to ensure the efficacy and safety of final products. It is primarily utilized in the pharmaceutical industry for the development of peptide-based therapeutics and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide drugs and active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected Fmoc-amino acid derivative for the controlled assembly of peptide chains.
• Proteomics Research: Used in the development of enzyme inhibitors, receptor ligands, and other biochemical tools for drug discovery.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and novel chemical entities.

Basic Information

Item	Detail
Product Name	1-Pyrrolidinecarboxylic Acid, 2-[(Carboxymethoxy)Methyl]-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2R)-
CAS No.	1335206-44-4
Molecular Formula	C23H23NO6
Molecular Weight	409.43 g/mol
Synonyms	(2R)-2-[(Carboxymethoxy)methyl]-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine; Fmoc-D-Glu(OtBu)-OH (tert-Butyl ester derivative precursor); Fmoc-D-γ-Glu(OtBu)-OH; N-α-Fmoc-D-glutamic acid γ-tert-butyl ester; N-Fmoc-D-glutamic acid 5-tert-butyl ester; (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-2-((2-((tert-butoxy)-2-oxoethoxy)methyl)pyrrolidine-2-carboxylic acid (related form); Protected D-Glutamic Acid Fmoc Derivative
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing. Quality is verified through comprehensive analytical techniques including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.