Description

3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-5-Methyl-Hexanoic Acid is a specialized Fmoc-protected amino acid derivative, a key building block in modern peptide synthesis. Its primary value lies in enabling the precise, sequential construction of complex peptides and peptidomimetics under solid-phase conditions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, diagnostic agents, and novel bioactive compounds. The compound, identified by CAS No. 1335042-37-9, is supplied to meet the stringent demands of advanced R&D and cGMP production environments.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected leucine derivative, it is a critical reagent for the controlled incorporation of specific amino acid residues into peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Peptidomimetic Design: Serves as a precursor for creating modified peptide structures with enhanced stability, bioavailability, or biological activity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation: The carboxylic acid functionality allows for conjugation to other molecules, carriers, or surfaces for diagnostic or targeted delivery applications.
• Academic & Institutional Research: A fundamental tool in biochemistry and molecular biology laboratories for studying protein structure-function relationships.

Basic Information

Product Name	3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-5-Methyl-Hexanoic Acid
CAS No.	1335042-37-9
Molecular Formula	C23H25NO5
Molecular Weight	395.45 g/mol
Synonyms	Fmoc-Leu-OH; Fmoc-L-leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-methylpentanoic acid; Nα-Fmoc-L-leucine; Fmoc-L-Leu; N-Fmocleucine; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-5-Methyl-Hexanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting or exceeding 98.5% (HPLC) purity standards. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support compliance requirements for research and production under cGMP, ISO, and other relevant regulatory frameworks. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.