Description

5-(4-Chloro-6-Quinazoliny)-2-Furancarboxaldehyde,Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined quinazoline-furan hybrid structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinazoline-based drug candidates targeting various kinases and other enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Oncology Drug Discovery: Particularly relevant for research into tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies due to the quinazoline pharmacophore.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Academic Research: Used in university and institutional labs for chemical biology studies and the exploration of new heterocyclic compounds with biological activity.

Basic Information

Product Name	5-(4-Chloro-6-Quinazoliny)-2-Furancarboxaldehyde,Hydrochloride
CAS No.	1334953-72-8
Molecular Formula	C₁₃H₈ClN₂O₂·HCl
Molecular Weight	297.13 g/mol (Free base: 260.67 g/mol)
Synonyms	5-(4-Chloro-6-quinazolinyl)-2-furancarboxaldehyde hydrochloride; 5-(4-Chloroquinazolin-6-yl)furan-2-carbaldehyde hydrochloride; 4-Chloro-6-(5-formylfuran-2-yl)quinazoline hydrochloride; 2-Furaldehyde, 5-(4-chloro-6-quinazolinyl)-, hydrochloride; CAS 1334953-72-8
EINECS	Contact for details

Quality Control

Our 5-(4-Chloro-6-Quinazoliny)-2-Furancarboxaldehyde,Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, residual solvent analysis (GC), and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.