Description

(2S,4S)-4-(Benzyloxy)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid is a high-purity, chiral Fmoc-protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for the controlled introduction of the (2S,4S)-4-(benzyloxy)proline moiety, enabling the creation of peptides with specific conformational and biological properties. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, peptide therapeutics development, and chemical biology studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Drug Discovery & Medicinal Chemistry: A crucial intermediate for constructing peptide-based drug candidates and peptidomimetics targeting various diseases.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: Serves as a chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Glycopeptide Synthesis: The benzyloxy-protected side chain can be a precursor for further functionalization, useful in synthesizing glycopeptide analogs.
• Academic & Industrial Research: A valuable reagent for exploring novel peptide structures and their functions in both academic and R&D settings.

Basic Information

Product Name	(2S,4S)-4-(Benzyloxy)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid
CAS No.	1334671-64-5
Molecular Formula	C28H25NO6
Molecular Weight	471.50 g/mol
Synonyms	Fmoc-(2S,4S)-4-(Benzyloxy)proline; Fmoc-Hyp(Bzl)-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(phenylmethoxy)-L-proline; (2S,4S)-1-Fmoc-4-(benzyloxy)pyrrolidine-2-carboxylic acid; Fmoc-trans-4-Benzyloxy-L-proline; N-α-Fmoc-trans-4-benzyloxy-L-proline; N-Fmoc-4-O-benzyl-trans-L-hydroxyproline; Fmoc-Hyp(Bn)-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and other critical parameters are available upon request. Our quality management system supports production for research and development use under cGMP-like controls where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require desiccant to protect from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.