Description

(E)-3-(3,4-Difluorophenyl)Acrylaldehyde is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its role in cross-coupling and cyclization reactions.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides with enhanced activity.
• Material Science: Building block for creating fluorinated polymers and liquid crystals with unique optical and electronic properties.
• Cross-Coupling Reactions: Serves as an electrophilic partner in Heck, Suzuki, and other palladium-catalyzed coupling reactions.
• Chemical Research: Valuable reagent for academic and industrial R&D in medicinal and synthetic organic chemistry.
• Fluorine Chemistry Studies: Used to investigate the influence of fluorine atoms on molecular reactivity and physicochemical properties.

Basic Information

Product Name	(E)-3-(3,4-Difluorophenyl)Acrylaldehyde
CAS No.	1334528-90-3
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	(E)-3-(3,4-Difluorophenyl)-2-propenal; trans-3-(3,4-Difluorophenyl)acrylaldehyde; 3-(3,4-Difluorophenyl)acrylaldehyde; (E)-3-(3,4-Difluorophenyl)propenal; 2-Propenal, 3-(3,4-difluorophenyl)-, (2E)-; 3,4-Difluorocinnamaldehyde; (E)-3,4-Difluorocinnamaldehyde
EINECS	Contact for details

Quality Control

Our (E)-3-(3,4-Difluorophenyl)Acrylaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from oxidizing agents and strong bases. Due to its sensitivity, allow the container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.