Description

(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(1-Methyl-1H-Indol-3-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a tryptophan side chain protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides containing modified tryptophan residues, enabling precise control over peptide structure and function. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and biotechnology who require reliable, high-quality intermediates for advanced peptide-based therapeutics and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptides and proteins.
• Pharmaceutical Research: Used in the development of peptide-based drugs, hormone analogs, and enzyme inhibitors targeting specific biological pathways.
• Bioconjugation: Serves as a precursor for creating peptide tags, fluorescent probes, and antibody-drug conjugates (ADCs).
• Chemical Biology & Proteomics: Enables the site-specific incorporation of modified tryptophan into peptides for studying protein-protein interactions and function.
• Agrochemical Development: Potential use in the synthesis of bioactive peptide analogs for crop protection.
• Material Science: Building block for designing peptide-based biomaterials and hydrogels with specific properties.

Basic Information

Product Name	(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(1-Methyl-1H-Indol-3-Yl)Propanoic Acid
CAS No.	1334509-86-2
Molecular Formula	C28H26N2O4
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-1-Methyl-L-tryptophan; Fmoc-1-Me-L-Trp-OH; Fmoc-1-Methyltryptophan; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoic acid; N-α-Fmoc-1-methyl-L-tryptophan; 1-Methyl-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-L-1-Me-Trp; Fmoc-1-Methyl-Trp
EINECS	Contact for details

Quality Control

Our (S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(1-Methyl-1H-Indol-3-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity suitable for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.