Description

Mal-Dpeg(R)11-Lipoamide CAS NO 1334172-73-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a lipoamide group at the other, connected by an 11-unit PEG spacer. This compound is engineered for precise and stable bioconjugation, where the maleimide group provides selective reactivity towards thiols (cysteine residues) under mild conditions, while the lipoamide moiety offers a versatile attachment point or a unique functional handle. It is an essential tool for researchers and manufacturers in biopharmaceutical development, diagnostic assay creation, and advanced material science applications requiring site-specific protein or peptide modification.

Application

• Site-specific protein PEGylation for improving pharmacokinetics and stability of therapeutic biologics.
• Antibody-drug conjugate (ADC) linker technology, connecting cytotoxic payloads to monoclonal antibodies.
• Surface functionalization of nanoparticles, biosensors, and chips for biomolecule immobilization.
• Crosslinking agent for studying protein-protein interactions or creating hydrogel networks.
• Fluorescent or affinity probe synthesis by conjugating dyes or tags to targeting molecules.
• Peptide cyclization or macrocycle formation via thiol-reactive chemistry.
• Liposome and drug delivery system modification to attach targeting ligands.
• Enzyme modification to alter solubility, activity, or stability for industrial biocatalysis.

Basic Information

Product Name	Mal-Dpeg(R)11-Lipoamide
CAS No.	1334172-73-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG11-Lipoamide; MAL-PEG11-Lipoamide; 3-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)oxy)-N-(5-((R)-1,2-dithiolan-3-yl)pentyl)-N-(17-oxo-4,7,10,13-tetraoxa-16-azaheptadecyl)propanamide; Lipoic acid-PEG11-maleimide; α-Lipoamide-ω-maleimide PEG; Heterobifunctional PEG linker, Maleimide-PEG-LA; Thiol-reactive PEG lipoamide.
EINECS	Contact for details

Quality Control

Our Mal-Dpeg(R)11-Lipoamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Maleimide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.